Avaliação e elucidação do mecanismo de ação de polímeros naturais modificados utilizados na agricultura / Evaluation and mode of action elucidation for modified natural polymers used in agriculture

Atualmente a agricultura ocupa um papel de extrema importância na conjuntura global e nacional e está inserida em um contexto de enormes desafios devido ao aumento da população mundial e maior demanda por alimentos. Ao mesmo tempo, é o setor mais afetado pelos impactos negativos das mudanças climáticas, que têm espalhado suas consequências de maneira cada vez mais frequente e intensa. Um dos principais efeitos é a alteração do regime de chuvas ao redor do globo, ocasionando estiagens intensas e duradouras, capazes de reduzir a produtividade de safras e comprometer a produção alimentícia. As abordagens atualmente existentes no mercado para mitigar as consequências negativas da escassez hídrica demandam alto investimento de implementação e manutenção, ou possuem um perfil ecotoxicológico insatisfatório. Polímeros de origem natural modificados quimicamente foram avaliados em termos de desempenho e capacidade de prover às plantas uma maior disponibilidade de água através de retenção hídrica. Os resultados alcançados demonstraram que os polímeros modificados com grupos iônicos foram capazes de promover um melhor gerenciamento hídrico no microambiente ao redor de sementes e entregar ganhos de produtividade a lavouras de soja. O mecanismo de ação da tecnologia estudada foi elucidado através de ensaios de determinação de capacidade de campo, análise de elipsometria, microscopia de força atômica, ensaios de germinação de soja sob estresse hídrico e implementação de áreas de soja a céu aberto a partir da aplicação em tratamento de sementes e sulco de plantio. As interações intra e intermoleculares entre as partículas de solo, moléculas de polímero e de água se mostraram ponto chave para a mudança de patamar de desempenho de polímeros naturais modificados utilizados na agricultura, quando comparados com os grupos controle. A tecnologia aqui estudada é, portanto, recomendada para utilização na agricultura, com capacidade de potencializar o efeito de tecnologias dependentes de água, resultando em maior produtividade na colheita

Nowadays agriculture occupies an extremely important role both in the global and national scenarios. Its included in a very challenging context due to the forecast of increased world population and consequent higher demand for food. At the same time, it is the most affected economic sector by the climate change effects, which have been causing frequent and harsh impacts. One of the main effects is the change in the rainfall pattern worldwide, which causes severe and long-lasting droughts, responsible for causing crops to fail and therefore putting food production at risk. The current available mitigation measures to address hydric scarcity require a huge investment for implementation and maintenance or do not present a satisfactory and safe ecotoxicological profile. Chemically modified natural polymers have been evaluated in terms of performance and ability to provide the plants with higher water availability through hydric retention. The results obtained show that such ionic group modified polymers are able to promote better water management in a given microenvironment surrounding the seeds and ultimately delivery a higher yield to soy crops. The technology's mode of action has been elucidated through field capacity determination trials, ellipsometry, atomic force microscopy, soy germination trials under hydric stress and, finally, implementation of soy areas under actual field conditions by applying the polymers via seed treatment and in-furrow methods. Both intra- and intermolecular interaction between soil particles, polymer and water molecules have been proven as key to understanding the agricultural performance improvement of the modified polymers when compared to the control. The technology is recommended for agricultural applications due to its ability to boost the effect of water-dependent technologies, promoting higher yields

Antioxidant status and their enhancements strategies for water stress tolerance in chickpea / Status antioxidante e suas estratégias de aprimoramento para tolerância ao estresse hídrico no grão-de-bico

Water stress executes severe influences on the plant growth and development through modifying physio-chemical properties. Therefore, a field experiment was designed to evaluate the antioxidant status and their enhancements strategies for water stress tolerance in chickpea on loam and clay loam soils under agro-ecological conditions of Arid Zone Research Institute, Bahawalpur (29.3871 °N, 71.653 °E) and Cholistan farm near Derawer (28.19°N, 71.80°E) of Southern Punjab, Pakistan during winter 2014-15. Experimental treatments comprised of two chickpea cultivars i.e. Bhakhar 2011 (drought tolerant) and DUSHT (drought sensitive), two water stress levels i.e. water stress at flowering stage and water stress at flowering + pod formation + grain filling stage including well watered (control) and two exogenous application of osmoprotectants i.e. glycine betaine (GB) 20 ppm and proline 10 uM including distilled water (control). Results indicated that water stress at various growth stages adversely affects the growth, yield and quality attributes of both chickpea cultivars. Exogenous application of GB and proline improved the growth, yield and quality parameters of both chickpea cultivars even under water stress conditions. However, superior results were obtained with exogenously applied GB on Bhakhar 2011 under well-watered conditions. Similarly, foliar spray of GB on chickpea cultivar Bhakhar 2011 under stress at flowering + pod formation + grain filling stage produced maximum superoxide dismutase, peroxidase and catalase contents. These results suggested that application of GB mitigates the adverse effects of water stress and enhanced tolerance in chickpea mainly due to higher antioxidant enzymes activity, demonstrating the protective measures of plant cells in stress condition. Hence, antioxidants status might be a suitable method for illustrating water stress tolerance in chickpea.

O estresse hídrico exerce fortes influências no crescimento e no desenvolvimento das plantas, modificando as propriedades físico-químicas. Portanto, a presente atividade de pesquisa foi projetada para avaliar o status antioxidante e suas estratégias de aprimoramento para tolerância ao estresse hídrico no grão-de-bico em condiçõesa groecológicas, no Instituto de Pesquisa da Zona Árida, Bahawalpur (29.3871 ° N, 71.653 ° E) e fazenda do Cholistan, perto de Derawer (28.19 ° N, 71,80 ° E), no sul de Punjab, Paquistão, durante Rabi 2014-15. Tratamentos experimentais compostos de dois genótipos de grão-de-bico, como Bhakhar 2011 (tolerante à seca) e DUSHT (sensível à seca), dois níveis de estresse hídrico, ou seja, estresse hídrico no estágio de floração, estresse hídrico na fase de floração e estresse hídrico na fase de floração + formação de vagem + estágio de enchimento de grãos, incluindo água bem controlada (controle) e duas aplicações exógenas de osmoprotetores, isto é, glicina betaína 20 ppm e prolina 10 uM, incluindo água destilada (controle). Os resultados indicaram que o estresse hídrico em vários estágios de crescimento afeta negativamente os atributos de crescimento, rendimento e qualidade de ambas as cultivares de grão-de-bico. A aplicação exógena de glicina betaína e prolina melhorou os parâmetros de crescimento, rendimento e qualidade de ambos os genótipos de grão- de-bico, mesmo sob condições de estresse hídrico. No entanto, resultados superiores foram obtidos com glicina betaína aplicada exogenamente em Bhakhar 2011, em condições bem regadas. Além disso, o spray foliar de glicina betaína na cultivar de grão-de-bico Bhakhar 2011, sob estresse na fase de floração + formação de vagem + enchimento de grãos, produziu o máximo de superóxido dismutase, peroxidase e catalase. Esses resultados sugeriram que a aplicação de glicina betaína atenua os efeitos adversos do estresse hídrico e aumenta a [...].

Hidratación en el síndrome urémico hemolítico / Hydration in hemolytic uremic syndrome

El síndrome urémico hemolítico asociado a diarrea es precedido por una gastroenteritis por Escherichia coli productora de toxina Shiga. Se recomiendan medidas de sostén, especialmente, la restricción hídrica para evitar la sobrecarga cardiopulmonar. Sin embargo, la expansión de volumen con líquidos isotónicos, en el período prodrómico o síndrome urémico hemolítico establecido, es segura y eficaz, reduce los requerimientos de diálisis, los días de internación y de terapia intensiva, los eventos neurológicos y la hiponatremia.Por ello, se propone, bajo supervisión nefrológica y/o garantizando el acceso a un centro de alta complejidad a corto plazo, hidratar a todo paciente sin signos de sobrecarga cardiopulmonar, independientemente de su función renal, con expansión inicial de volumen. Luego, si se logra una diuresis adecuada, no dializarlo (excepto que presente un trastorno metabólico/electrolítico intratable médicamente) y continuar la hidratación con una solución isotónica de dextrosa al 5 % para una adecuada hidratación y diuresis.

Diarrhea-associated hemolytic uremic syndrome is preceded by gastroenteritis due to Shiga toxin-producing Escherichia coli. Support measures are recommended, specifically, fluid restriction to avoid cardiopulmonary overload. However, in the prodromal period or with established hemolytic uremic syndrome, volume expansion with isotonic fluids is safe and effective, and reduces the need for dialysis, the length of hospital and intensive care stay, neurological events, and hyponatremia.Therefore, when nephrological monitoring is available and/or short-term access to a tertiary care hospital is guaranteed, it is suggested to hydrate patients with no signs of cardiopulmonary overload, regardless of their renal function, with initial volume expansion. Afterwards, if an adequate urine output is achieved, the patient should not be dialyzed (except if they have a medically intractable metabolic/electrolyte disorder) and hydration should be continued with an isotonic solution containing 5 % dextrose for adequate hydration and urine output.

Hipodermóclise para correção de desidratação hiperosmolar e distúrbios eletrolíticos graves: relato de caso / Hypodermoclysis for correction of hyperosmolar dehydration and severe electrolyte disturbances: a case report

O tratamento de desidratação e distúrbios eletrolíticos graves é contraindicado por meio de hipodermóclise, mas o nível de evidência da recomendação se baseia na opinião de especialistas. Descreve-se caso clínico de paciente com idade avançada, com indicação de cuidados paliativos, que evoluiu com desidratação hiperosmolar com hipernatremia grave, injúria renal aguda e hipercalemia. Tratou-se a paciente com solução hipotônica por meio da técnica de hipodermóclise, com resolução completa do quadro. Conclui-se que há necessidade de mais estudos sobre o uso da hipodermóclise para o tratamento de distúrbios hidroeletrolíticos graves.

The treatment of dehydration and severe electrolyte disturbances using hypodermoclysis is usually contraindicated, but the level of evidence for its recommendation is based on expert opinion. This case report describes an older patient receiving palliative care who developed hyperosmolar dehydration with severe hypernatremia, acute kidney injury, and hyperkalemia. She was treated with hypodermoclysis using a hypotonic solution, which led to complete resolution of the condition. In conclusion, further studies on the use of hypodermoclysis for the treatment of severe hydroelectrolytic disorders are needed.

Características sociodemográficas y clínico-epidemiológicas de los pacientes adultos ingresados por diarrea del viajero en la Clínica Internacional Trinidad, 2015-2017 / Sociodemographic and clinical-epidemiological characteristics of patients admitted for traveler's diarrhea to Trinidad International Clinic, 2015-2017

Introducción: La diarrea del viajero es causa frecuente de hospitalización en turistas internacionales. Objetivo: Describir las características sociodemográficas y clínico-epidemiológicas de los pacientes adultos ingresados por diarrea del viajero en la Clínica Internacional de Trinidad durante los años 2015 al 2017. Métodos: Estudio descriptivo de los 699 pacientes adultos con diarrea del viajero que requirieron de ingreso en el periodo de estudio. Se revisaron sus historias clínicas para analizar la frecuencia en que estuvieron presentes algunas variables sociodemográficas y clínico-epidemiológicas. Para analizar los datos se utilizó la estadística descriptiva con distribución de frecuencias y porcentajes. Resultados: El grupo etario entre 19 y 40 años tuvo un 60,52 por ciento de pacientes afectados; el 58,23 por ciento en el sexo femenino, con una incidencia mayor en los meses de julio (12,88 por ciento) y febrero (12,44 por ciento). Los viajeros procedentes de países europeos representaron el 76,97 por ciento ; el 74,96 por ciento se hospedó en casas particulares. El 1,85 por ciento de los afectados presentaba antecedentes de enfermedad gastrointestinal; el 76,11 por ciento requirió de 1 a 6 h de observación, con deshidratación leve (59,66 por ciento) y moderada (21,75 por ciento). El vómito y las náuseas se presentaron en el 58,37 por ciento de los pacientes y en el 60,73 por ciento la causa no fue precisada. Conclusiones: Las variables sociodemográficas y clínico-epidemiológicas seleccionadas permitieron describir características de los pacientes adultos ingresados por diarrea del viajero. Se recomienda profundizar en el estudio para contribuir a su prevención y optimizar la atención(AU)

Introduction: Traveler's diarrhea is a frequent cause of hospitalization of international tourists. Objective: Describe the sociodemographic and clinical-epidemiological characteristics of adult patients admitted for traveler's diarrhea to Trinidad International Clinic in the period 2015-2017. Methods: A descriptive study was conducted of the 699 adult patients with traveler's diarrhea who required hospitalization in the study period. The patients' medical records were reviewed to analyze the frequency of some sociodemographic and clinical-epidemiological variables. Data analysis was based on descriptive statistics with frequency and percentage distribution. Results: 60.52 percent of the patients affected were in the 19-40 years age group, 58.23 percent were female, and the highest incidence was observed in the months of July (12.88 percent) and February (12.4 4 percent ). Travelers from European countries represented 76.97 percent, and 74.96 percent were staying in private dwellings. Of the patients affected, 1.85 percent had a history of gastrointestinal disease; 76.11percent required 1-6 hours of observation; dehydration was mild in 59.66 percent and moderate in 21.75 percent. Vomiting and nausea were present in 58.37 percent of the patients; in 60.73 percent the cause was not determined. Conclusions: The sociodemographic and clinical-epidemiological variables selected made it possible to characterize the adult patients admitted for traveler's diarrhea. Further research is recommended to contribute to the prevention this disease. Further research is recommended to contribute to the prevention this disease and optimize care(AU)

Caracterización de las complicaciones de los pacientes diagnosticados con cólera en el Hospital Pediátrico de Centro Habana, 2013-2017 / Characterization of the complications of patients diagnosed with cholera in the Pediatric Hospital of Centro Habana, 2013-2017

Introducción: La séptima pandemia del cólera llegó a las Américas en 1991. En Cuba hacía más de 130 años no se registraba ningún caso. Objetivos: Identificar y caracterizar las complicaciones por cólera y su relación con características clínicas y de tratamiento. Métodos Se realizó un estudio descriptivo y prospectivo desde el año 2013-2017 a los pacientes a los que se les confirmó el V. cholerae como causa exclusiva de enfermedad diarreica aguda. Las variables cualitativas se describieron estadísticamente mediante frecuencias absolutas y relativas y para las variables cuantitativas se utilizó la media, la mediana, la desviación estándar y el rango intercuartílico como medidas de dispersión. Resultados: El 36,5 por ciento de los enfermos presentó complicaciones donde la deshidratación fue la más frecuente. El valor de la mediana del tiempo que medió entre la aparición de los síntomas y la atención en el centro fue menor en los pacientes con complicaciones comparado con el observado en los no complicados, pero la diferencia no fue significativa: (24 horas [RI: 24,0-72,0 horas] vs. 48 horas [RI: 24,0-72,0 horas], p= 0,355). Conclusiones: La mayoría de los enfermos no presentaron complicaciones y la más frecuente es la deshidratación ligera(AU)

Introduction: The seventh cholera pandemic arrived to the Americas in 1991. In Cuba for more than 130 years there were no case reports. Objectives: To identify and characterize the complications by cholera and its relation with clinical characteristics and treatment. Methods: A descriptive and prospective study was conducted from 2013 to 2017 to the patients who had been confirmed with V. cholerae as exclusive cause of acute diarrheal disease. The qualitative variables were described statistically using absolute and relative frequencies, and for the quantitative variables were used the average, medium, and standard deviation and the interquartile range as dispersion measures. Results: 36.5 percent of the patients presented complications where dehydration was the most frequent. The value of the median time between the onset of symptoms and attention in the center was lower in patients with complications in comparison with the observed in non-complicated patients, but the difference was not significant (24.0 h [RI: 24,0-72,0 h] vs. 48,0 h [RI: 24,0-72,0 h], p= 0.355). Conclusions: Most of the patients did not present complications and the most frequent is the slight dehydration (AU)

La determinación económica, social y laboral de la enfermedad renal crónica de causas no tradicionales (ERCnT) en la costa sur de Guatemala / The economic, social and labor determination of chronic kidney disease of non-traditional causes (CKDnT) on the southern coast of Guatemala

La flexibilidad laboral es característica de la producción estacional agroindustrial, cuyo principal problema es aprovechar con intensidad los períodos en los que se incrementa la producción. Pero, ¿cómo la demandante competitividad laboral influye en las estrategias de los trabajadores para incrementar su productividad? A partir de esta pregunta, se identificaron los aspectos económicos, sociales y laborales que inciden en la salud, así como las respuestas para disminuir el dolor físico y aumentar las exigencias de competitividad, flexibilización y desregularización del mercado de trabajo. La exposición ambiental y ocupacional en las condiciones de trabajo, el estrés térmico asociado a la deshidratación en la actividad física intensa, el limitado acceso a los servicios de salud, la mala alimentación y la pobre calidad de vida, también pueden producir otras enfermedades como diabetes e hipertensión, así como infecciones y lesiones renales. En ese contexto, en los últimos 20 años, se empezaron a reportar casos de enfermedad renal. La metodología cualitativa aplicada a este estudio, permitió llevar a cabo un proceso investigativo descriptivo e interpretativo sobre la forma en que los sujetos interactúan. Para ello se utilizaron las trayectorias laborales como técnicas en la recolección de datos. Los resultados arrojaron información relevante sobre las estrategias que los trabajadores utilizan para incrementar su rendimiento laboral, entre ellas la automedicación de vitaminas y analgésicos para tratar los espasmos musculares, que estimulan el sistema nervioso central, así como de bebidas saborizadas y energizantes con posibles repercusiones en la excreción renal.

Labor flexibility is characteristic of seasonal agroindustrial production whose main problem is to take advantage of the periods in which production increases. But, how does this demanding labor competitiveness influence workers' strategies to increase their productivity? From this question, the economic, social and labor aspects that affect health were identified, as well as the answers to reduce physical pain and increase the demands for competitiveness, flexibility and deregulation of the labor market. Environmental and occupational exposure in working conditions, thermal stress associated with dehydration in intense physical activity, limited access to health services, poor diet and quality of life, can also cause other diseases such as diabetes and hypertension, as well as infections and kidney lesions. In that context, in the last 20 years, cases of kidney disease began to be reported. The qualitative methodology applied to this study, allowed to carry out a descriptive and interpretive investigation process on the way in which the subjects interact, for this, the work trajectories were used as techniques in data collection. The results yielded relevant information on the strategies that workers use to increase their work performance, including self-medication of "vitamins" and analgesics to treat muscle spasms, drugs that stimulate the central nervous system, as well as flavored and energizing drinks with possible repercussions on renal excretion.

Desidratação, acidente vascular cerebral e disfagia: revisão sistemática da literatura / Dehydration, stroke and dysphagia: systematic review

RESUMO Objetivos trata-se de revisão sistemática da literatura científica sobre a associação entre o acidente vascular cerebral, desidratação e disfagia orofaríngea. Estratégia de pesquisa o levantamento bibliográfico foi realizado nas bases de dados científicos: MEDLINE, LILACS, SciELO, Web of Science e Cochrane. Critérios de seleção foram incluídos os estudos que preencheram os seguintes critérios de inclusão: ser artigo original, com resumo disponível; ter sido publicado entre os anos de 2001 e 2018 e nos idiomas português, inglês ou espanhol; abordar o tema desidratação em indivíduos após acidente vascular cerebral. A triagem e análise dos estudos foram realizadas por dois avaliadores independentes. Resultados dentre os 484 artigos localizados para a triagem, 43 foram selecionados para leitura completa e 18 foram incluídos na análise final. Foram descritos diferentes métodos de avaliação do estado de hidratação nos indivíduos após acidente vascular cerebral, tais como: análise da relação BUN /creatinina, osmolaridade plasmática, relação ureia/creatinina, gravidade específica da urina, coloração da urina, ingestão hídrica, balanço hídrico, bioimpedância elétrica, avaliação clínica, análise de eletrólitos isolados. A prevalência de desidratação em pacientes após acidente vascular cerebral, durante a internação, variou de 11% a 66% e está associada à gravidade e piora na evolução clínica. Conclusão foi possível compreender a complexidade do processo de mensuração do estado de hidratação em indivíduos após acidente vascular cerebral e sua associação com a disfagia. Estudos enfocando essa temática são de extrema relevância, visto a sua influência sobre a taxa de mortalidade e morbidade nesta população.

ABSTRACT Purpose this is a systematic review of scientific literature associated with stroke, dehydration and oropharyngeal dysphagia (OD). Research Strategy bibliographic survey was conducted in scientific databases: MEDLINE, LILACS, SciELO, Web of Science and Cochrane. Selection criteria studies that met the following inclusion criteria were included: being original article with summary available; have been published in the last seventeen years (2001-2018) and in Portuguese, English or Spanish languages; and addressing dehydration in individuals after stroke Screening and analysis of the studies were performed by two independent evaluators. Results among the 484 articles found for screening, 43 were selected for full reading and 18 articles were included in the final analysis. Different methods of assessing hydration status have been described in individuals post-stroke, such as ratio analysis blood urea nitrogen (BUN)/creatinine, plasma osmolality, urea / creatinine, urine specific gravity, urine color, water intake, water balance, bioelectrical impedance analysis (BIA), clinical evaluation and analysis of electrolytes. The prevalence of dehydration in post-stroke during hospitalization varied from 11% to 66% and is associated with severity and deterioration in the clinical evolution. Conclusion It was possible to understand the complexity of the measurement of hydration status in individuals after stroke and its association with dysphagia. Studies focusing on the association between dehydration and stroke are very important, due to its influence on mortality and morbidity in this population.

Paradoxical Heart Failure Precipitated by Profound Dehydration: Intraventricular Dynamic Obstruction and Significant Mitral Regurgitation in a Volume-Depleted Heart

Occurrence of dynamic left ventricular outflow tract (LVOT) obstruction is not infrequent in critically ill patients, and it is associated with potential danger. Here, we report a case of transient heart failure with hemodynamic deterioration paradoxically induced by extreme dehydration. This article describes clinical features of the patient and echocardiographic findings of dynamic LVOT obstruction and significant mitral regurgitation caused by systolic anterior motion of the mitral valve in a volume-depleted heart.

Hiperpotassemia: conduta sinoventricular em paciente idoso, em insuficiência renal e cetoacidose diabética / Hyperpotassemia and sinoventricular conduction in elderly patient with renal insufficiency and diabetic ketoacidosis

Paciente idoso, portador de cardiomiopatia isquêmica, hipertenso, com leve disfunção renal e diabético insulinodependente, por suspensão do uso da insulina desenvolveu cetoacidose com grave desidratação e severa hiperpotassemia, que reverteu com o uso de medicações. Analisam-se interessantes aspectos eletrocardiográficos inerentes ao caso.

An elderly patient with ischemic cardiomyopathy, hypertension, slight renal dysfunction and insulindependentdiabetes developed ketoacidosis aftersuspending insulin use, with severe dehydration and severe hyperpotassemia, both reverted throughmedications. This paper analyzes interesting eletrocardiographic aspects of this case.

Hypernatremia among in-patients of a General Hospital in Kuwait

To determine the incidence and aetiology of Hypernatremia in adult patients admitted to a general hospital in Kuwait as it has not been studied as frequently as hyponatremia. A hospital based retrospective study carried out between July 2009 to Dec 2009. Medical inpatient wards, department of medicine, Al-Jahra hospital, Kuwait. 92 hypernatremia patients [41 males and 51 females] of the total 1825 patients were analyzed and their aetiology studied. Frequency, aetiology and outcome of Hypernatremia in adult inpatients. All blood samples were analyzed in biochemistry department on LX20 machine. Information regarding age, gender, highest serum sodium levels, clinical diagnoses and further clinical information suggesting causes of hypernatremia was gathered. Results: Of the total 1825 patients analyzed, 5.04% were diagnosed with hypernatremia with a mean serum sodium of 150.9 mmol/L. Among major causes of hypernatremia were hyperglycemia [21.7%], IV fluids [21.7%] and dehydration [17.4%] The overall incidence of hypernatremia in this hospital was 5.04%. Hyperglycemia and IV fluid administration were the commonest causes. Prompt treatment of hypernatremia is necessary but care should be taken to avoid excessively rapid correction or overcorrection, which increases the risk of iatrogenic cerebral edema

Acute renal failure as complication of diarrhea in children in Al Diwaniyah

This is a Prevalence study of renal failure as complication of patients had diarrhea and dehydration Who admitted in Maternity and children Teaching Hospital in AL-Diwaniya from 1/8/2008 to 1/8/2009 The total number of Patients was 5171 patients, those <1y of age [23.12%] male and [19.76%] female, from 1-4 y. of age [22.10%] male and [18.29%] female, from 5-14 y age [9.16%] male and [7.24%] female, the male to female ratio was 1.19: 1. The total number of patients had ARF and peritoneal dialysis were 19 Patients [0.36%] of total number of patients 5 1 7 1 patients, 57 them died [0.09%] after dialysis and 14 discharged well [0.27%] from hospital after peritoneal dialysis

Liver functions changes in acute diarrhea in children

Diarrhea is considered to be one of the most common causes of morbidity and mortality among infants and children in developing countries. The present study was done to evaluate the incidence of hepatic affection or the occurrence of abnormal liver functions in infants and children presented with acute diarrhea with different degrees of dehydration. The study demonstrated that total number of patients with liver function impairment were [22.5% of cases]. All of them had elevated AST, either single elevation in 60% of cases with impaired liver function or combined AST and ALT elevation in 40% of cases with impaired liver function. The mean value of AST was 95 u /1 +/- 75.4, where mean value of ALT was 124 u/l +/- 8-5.8

Cerebral sinovenous thrombosis in children

Cerebral sinovenous thrombosis in childhood is a serious disease. There are many predisposing and influencing factors which should be unraveled to identify patients at risk and to establish treatment regimens in children. We report two cases, in which the predisposing risk factors for the cerebral sinovenous thrombosis were antithrombin III deficiency in one case, and severe dehydration in the other. In both cases diagnosis was confirmed by standard imaging methods, computerized tomography [CT] followed by magnetic resonance imaging/venography [MRI and MRV]

Perfil de la diarrea aguda en niños hospitalizados de Santa Bárbara / Profile of acute diarrhea in hospitalized children from Santa Barbara

Introducción: la diarrea aguda ha sido una de las principales causas de morbilidad y mortalidad en la infancia. Estudiar el comportamiento clínicos y epidemiológico de la diarrea en menores de cinco años ingresados en el Servicio de Pediatría del Hospital Santa Bárbara Integrado de Honduras durante los primeros cinco meses del año 2008. Pacientes y métodos: El universo estuvo constituido por 200 niños desde cero hasta cinco años que ingresaron en el servicio con el diagnóstico de Enfermedad Diarreica Aguda en el transcurso de una epidemia. Se utilizó un cuestionario que fue aplicado a las madres y además se utilizó información de los expedientes clínicos de los pacientes. Resultados: La afectación fue en el amplio grupo de 1 hasta 4 años, con predominio en el sexo masculino y la mayoría de los pacientes estaban eutróficos. El bajo percápita familiar, el hacinamiento y la baja escolaridad materna fueron los principales antecedentes de riesgo detectados. La deshidratación fue la principal complicación y no ocurrieron defunciones. Conclusión: Los hallazgos clínicos y epidemiológicos encontrados en este grupo indican que las condiciones socioeconómicas se asocian a enfermedad diarreica...

[Cerebral venous thrombosis complicating a severe dehydration in the infant about a case report]

Cerebral venous thrombosis [CVT] is a rare vascular pathology in the infant characterized by a clinical and etiologic diversity. We report the case of CVT secondary to a severe deshydratation. It is about a one month old infant without notable pathological antecedents which presented 5 days before its hospitalization a refusal of feeding, a disorder of behavior and somnolence. The initial assessment showed a urinary infection with negative gram bacillus and a functional renal insufficiency. In front of the non improvement under treatment and the aggravation of the renal insufficiency, the patient was transferred to our formation. At admission the examination found an apyretic, icteric and hypertonic infant with dehydration of more than 15%and a convex anterior fontanella. Transfontanellar echography showed signs of cerebral haemorrhage and the CT-scan revealed a wide cerebral thrombosis. In spite of the rehydration and the antibioc, the patient deceased following a bradycardia with haemodynamic instability non responding to vaso-active drugs. The TVC is an unusual complication of deshydration in the infant. Through this observation the authors discuss the mechanisms of the TVC

Effects of Tissucol™ and epsilon aminocaproic acid in the healing process following dental extraction in dehydrated rats

Foi estudada histologicamente a reparação do alvéolo dental de ratos desidratados, após o implante de adesivo fibrínico (TISSUCOL®) associado à irrigação prévia da ferida com solução a 5% de ácido épsilon-aminocapróico. Foram empregados 72 ratos, divididos em três grupos, que receberam diferentes tratamentos após o procedimento cirúrgico. No Grupo I, após a extração do incisivo superior direito, a mucosa gengival foi suturada. Nos Grupos II e III foi provocada a desidratação crônica pela privação de ingestão de líquidos durante 09 dias (3 dias no pré-operatório e 6 dias no pós-operatório), sendo que, no Grupo II, após a extração dental, a mucosa gengival foi suturada de forma semelhante à do Grupo I; no Grupo III, logo após a exodontia, o alvéolo foi irrigado com a solução de ácido épsilon-aminocapróico a 5%, seguida de implante de adesivo fibrínico (TISSUCOL®) e foi feita sutura da mucosa de forma semelhante à dos demais grupos. Decorridos 3, 7, 15 e 21 dias após o ato operatório, os animais foram sacrificados em número de 6 para cada grupo. A seguir, as peças contendo o alvéolo dental foram removidas e fixadas em formalina a 10% e descalcificadas em solução de ácido fórmico e citrato de sódio em partes iguais. Após processamento laboratorial de rotina, foram incluídas em parafina para microtomia. Foram obtidos cortes semi-seriados com 6 micrômetros de espessura, seguidos de coloração em hematoxilina e eosina para estudo microscópico. Os resultados obtidos mostram que a hidroprivação no pré e pós-operatório ocasiona profundo retardo no processo de reparo em feridas de extração dental. O emprego de adesivo fibrínico (TISSUCOL®) melhora o quadro fibrinolítico provocado pela desidratação.